Regular Article| Volume 8, ISSUE 4, P250-252, June 1999

Download started.


Carbamazepine, hepatotoxicity, organic solvents, and paints

      This paper is only available as a PDF. To read, Please Download here.


      Hepatotoxicity secondary to carbamazepine is a serious condition which can be fatal. However, other concomitant medications or environmental factors may be the offending agents. In this case report, hepatotoxicity secondary to organic solvents and paints is described.




        • Frances A.
        • Doherty J.P.
        • Kuhn D.A.
        The expert consensus guideline series—treatment of bipolar disorder.
        Journal of Clinical Psychiatry. 1996; 57: 1-88
        • Post R.M.
        • Altshuler L.L.
        • Ketter T.A.
        • Denicoff K.
        • Weiss S.R.
        Antiepileptic drugs in affective illness: clinical and theoretical implications.
        Advances in Neurology. 1991; 55: 239-277
        • Wyllie E.
        • Wyllie R.
        Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy.
        Epilepsia. 1991; 32 (Suppl. 5): S74-S79
        • Dreifuss F.E.
        • Langer D.H.
        Hepatic considerations in the use of antiepileptic drugs.
        Epilepsia. 1987; 28 (Suppl. 2): S23-529
        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association, Washington1994
        • Horowitz S.
        • Patwardhan R.
        • Marcus E.
        Hepatotoxic reactions associated with carbamazepine therapy.
        Epilepsia. 1988; 29: 149-154
        • Davion T.
        • Capron J.P.
        • Andrejak M.
        • Geoffroy P.
        • Capron-Chivrac D.
        • Quenum C.
        Acute hepatitis due to carbamazepine: study of a case and review of the literature.
        Gastroenterologie Clinique et Biologique. 1984; 8: 52-56
        • Levy M.
        • Goodman M.W.
        • Van Dyne B.J.
        • Sumner H.W.
        Granulomatous hepatitis secondary to carbamazepine.
        Annals of Internal Medicine. 1981; 95: 64-65
        • Levander H.G.
        Granulomatous hepatitis in a patient receiving carbamazepine.
        Acta Medica Scandinavica. 1980; 208: 333-335
        • Dossing M.
        • Arlien-Soborg P.
        • Milling Petersen L.
        • Ranek L.
        Liver damage associated with occupational exposure to organic solvents in house painters.
        European Journal of Clinical Investigations. 1983; 13: 151-157
        • Chen J.D.
        • Wang J.D.
        • Jang J.P.
        • Chen Y.Y.
        Exposure to mixtures of solvents among paint workers and biochemical alterations of liver function.
        British Journal of Industrial Medicine. 1991; 48: 696-701
        • Sotaniemi E.A.
        • Sutinen S.
        • Arranto A.J.
        • Pelkonen R.O.
        Liver injury in subjects occupationally exposed to chemicals in low doses.
        Acta Medica Scandinavica. 1982; 212: 207-215
        • Lundberg I.
        • Hakansson M.
        Normal serum activities of liver enzymes in Swedish workers with heavy exposure to organic solvents.
        British Journal of Industrial Medicine. 1985; 42: 596-600
        • Toskulkao C.
        • Nhongsaeng J.
        • Glinsukon T.
        Potentiation of carbon tetrachloride induced hepatotoxicity by thinner inhalation.
        Journal of Toxicological Sciences. 1990; 15: 75-86