Knight and colleagues must be commended for their cross-sectional study from the UK
Epilepsy and Pregnancy Register evidencing that children exposed to topiramate in
utero had poorer levels of adaptive behaviour with a dose response effect [
[1]
].Keywords
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References
- Adaptive behaviour in children exposed to topiramate in the womb: an observational cohort study.Seizure. 2023; 105: 56-64
- Preliminary findings of the developmental effects of in utero exposure to topiramate.Reprod Toxicol. 2012; 34: 308-311
- Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability.JAMA Neurol. 2022; 79 ([published correction appears in JAMA Neurol. 2022 Jul 1;79(7):727]): 672-681
- In utero exposure to antiepileptic drugs is associated with learning disabilities among offspring.J Neurol Neurosurg Psychiatry. 2018; 89: 1324-1331
- Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population- based cohort study.BMJ Open. 2020; 10e034829
- Topiramate during pregnancy and the risk of neurodevelopmental disorders in children.in: Proceedings of the 38th international conference on pharmacoepidemiology and therapeutic risk management, Copenhagen, Denmark31. 2022: 47 (26–28 August 2022Harmacoepidemiology and Drug Safety#)
- Association of folic acid supplementation during pregnancy with the risk of autistic traits in children exposed to antiepileptic drugs in utero.JAMA Neurol. 2018; 75: 160-168
- [Topiramate and risks in children exposed during pregnancy: modification of the conditions of prescription and delivery to the women concerned].Agence Natl Sécur Méd Prod Santé. 2022; (6 Octoberupdated 2 November 2022. Available at) (Accessed 4 March 2023)
- Topiramate.Drug Usage Statistics, United States2020 (2013 –Available at) (Accessed 4 March 2023)
- Pregnant women should be included in clinical trials to improve outcomes, says commission.BMJ. 2022; 377: o1193
- Prenatal exposure to teratogenic medications in the era of risk evaluation and mitigation strategies.Am J Obstet Gynecol. 2022; 227: 263.e1-263.e38
- Contraceptive provision to adolescent females prescribed teratogenic medications.Pediatrics. 2016; 137https://doi.org/10.1542/peds.2015-1454
Article info
Publication history
Published online: March 15, 2023
Accepted:
March 14,
2023
Received:
March 11,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.