The KCNQ2 gene encodes voltage-gated potassium channel subunits that underlie the M-current, a repolarizing current that limits repetitive firing during long-lasting depolarizing inputs [
]. Mutations in this gene can result in disorders ranging from benign familial neonatal convulsions (BFNC) to early infantile developmental and epileptic encephalopathy (EIDEE) [
- Wang H.S.
- Pan Z.
- Shi W.
- Brown B.S.
- Wymore R.S.
- Cohen I.S.
- et al.
KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
Science. 1998; 282: 1890-1893
- Goto A.
- Ishii A.
- Shibata M.
- Ihara Y.
- Cooper E.C.
- Hirose S.
Characteristics of KCNQ2 variants causing either benign neonatal epilepsy or developmental and epileptic encephalopathy.
Epilepsia. 2019; 60: 1870-1880
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- KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.Science. 1998; 282: 1890-1893
- Characteristics of KCNQ2 variants causing either benign neonatal epilepsy or developmental and epileptic encephalopathy.Epilepsia. 2019; 60: 1870-1880
- Clinical study of 30 novel KCNQ2 variants/deletions in KCNQ2-related disorders.Front Mol Neurosci. 2022; 15809810
- A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon.J Neurosci. 2006; 26: 2599-2613
Published online: March 12, 2023
Accepted: March 11, 2023
Received in revised form: March 2, 2023
Received: November 22, 2022
Publication stageIn Press Journal Pre-Proof
© 2023 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.