Highlights
- •Cluster analysis showed that there were two distinct clusters of homogeneous subgroups of patients with JME.
- •Response to treatment was different between the clusters (as a trend) (p = 0.076).
- •It is ideal to apply this technique of statistical analysis on a very large dataset of patients in a multicenter study.
Abstract
Objectives
The purpose of the current study was to apply Two-step cluster analysis on a large
dataset of patients with juvenile myoclonic epilepsy (JME). We hypothesized that there
are distinct subgroups of patients with similar clinical characteristics. We also
hypothesized that the seizure outcome is different between these clusters.
Methods
This was a retrospective study of a prospectively developed database. All patients
with a diagnosis of JME were studied at the epilepsy center at Shiraz University of
Medical Sciences, Shiraz, Iran, from 2008 until 2022. The Two-Step cluster analysis
(Schwarz's Bayesian Criterion) was applied to the whole dataset. In the next step,
the seizure outcome was compared between the clusters of patients.
Results
Two hundred and ninety-five patients were included. Two-Step cluster analysis showed
that there were two distinct clusters of homogeneous subgroups of patients with JME,
presenting with more or less similar clinical characteristics, with a fair (0.4) silhouette
measure of cohesion and separation. One hundred and eighty-one patients had a follow
up duration of 12 months or longer at our center. Response to treatment at 12 months
of follow-up was different between the clusters (as a trend): 43 patients (39.1%)
from cluster 1 and 18 people (25.4%) from cluster 2 were free of all seizure types
(p = 0.076).
Conclusion
The Two-Step cluster analysis identified two distinct clusters of patients with JME.
Individuals with JME, who also have absence seizures, are less likely to enjoy a seizure
free state with ASMs.
Keywords
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Article info
Publication history
Published online: January 10, 2023
Accepted:
January 9,
2023
Received in revised form:
January 7,
2023
Received:
October 24,
2022
Identification
Copyright
© 2023 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
