Highlights
- •Patients with JME have worse sleep quality and a more evening chronotype.
- •Epilepsy-related factors did not predict the performance on sleep scales.
- •Pharmacoresponsiveness was associated with lower depressive and anxiety scores.
- •Pharmacoresistant JME patients had a worse sleep quality than pharmacoresistant.
Abstract
Purpose
This study evaluated sleep quality, chronotype, and excessive diurnal somnolence in
persons with Juvenile Myoclonic Epilepsy (JME) and their possible association with
clinical variables.
Methods
This cross-sectional controlled study evaluated 49 consecutive patients (65% females,
mean age 27.53 years) with an electroclinical diagnosis of JME and 49 healthy controls
(55% females, mean age 28.55 years). The Pittsburgh Sleep Quality Inventory (PSQI)
was used to assess sleep quality and the Epworth Sleepiness Scale (ESS) to evaluate
excessive daytime sleepiness. The patients' chronotype was evaluated by the Morningness-Eveningness
Questionnaire (MEQ). Epilepsy-related factors gathered from the medical chart and
personal interview were epilepsy duration, age at onset, frequency of myoclonic (Mcl),
generalized tonic-clonic (GTC) and absence (ABS) seizures, pharmacoresponse, and current
antiseizure medication (ASM).
Results
Persons with JME did not differ from the control group regarding daytime sleepiness
(p=0.840); however, the JME group had worse sleep quality (p=0.01) than the controls.
Persons with JME presented a more evening chronotype than controls (p = 0.003). The
age at onset, epilepsy duration, frequency of Mcl seizure, frequency of GTC seizure,
frequency of ABS seizure, and drug response did not predict ESS and MEQ scales. Pharmacoresponsive
patients had lower PSQI scores compared with pharmacoresistant patients (p=0.036).
Conclusion
Persons with JME have worse sleep quality and a more evening chronotype. Notably,
pharmacoresistant patients present a worse sleep quality that deserves attention and
special care due to the relationship between sleep deprivation and seizure worsening.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Seizure - European Journal of EpilepsyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Juvenile myoclonic epilepsy: challenges on its 60th anniversary.Seizure. 2017; 44: 48-52
- The crosstalk between physiology and circadian clock proteins.Chronobiol Int. 2009; 26: 1479-1513
- 3rd Temporal distribution of partial seizures: comparison of an animal model with human partial epilepsy.Ann Neurol. 1998; 43: 748-755
- Temporal distribution of clinical seizures over the 24-h day: a retrospective observational study in a tertiary epilepsy clinic.Epilepsia. 2009; 50: 2019-2026
- Dissociable cortical processing of recognizable and non-recognizable biological movement: analysing gamma MEG activity.Cereb Cortex. 2004; 14: 181-188
- Temporal distributions of seizure occurrence from various epileptogenic regions.Neurology. 2008; 70: 1265-1271
- Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?.Epilepsy Behav. 2009; 16: 461-467
- Circadian rhythms: interactions with seizures and epilepsy.Epilepsy Res. 2000; 42: 43-55
- Impulsiv-Petit mal.Deutsche Zeitschrift für Nervenheilkunde. 1957; 176: 346-386
- Circadian rhythm and personality profile in juvenile myoclonic epilepsy.Epilepsia. 2006; 47: 111-114
- Sleep abnormalities in juvenile myoclonic epilepsy-A sleep questionnaire and polysomnography based study.Seizure. 2017; 50: 194-201
- Sleep disturbances in juvenile myoclonic epilepsy: a sleep questionnaire-based study.Epilepsy Behav. 2012; 23: 305-309
- Impact of sleep disorders on the risk of seizure recurrence in juvenile myoclonic epilepsy.Epilepsy Behav. 2018; 80
- Reduced sleep quality is related to poor quality of life in patients with juvenile myoclonic epilepsy, a case-control study.Life (Basel). 2022; 12
- Consensus on diagnosis and management of JME: from founder's observations to current trends.Epilepsy Behav. 2013; 28: S87-S90
- A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.Int J Chronobiol. 1976; 4: 97-110
- A self-assessment questionnaire for the determination of morningness-eveningness types in Brazil.Prog Clin Biol Res. 1990; 341b: 89-98
- Comparing the morningness-eveningness questionnaire and Munich chronotype questionnaire to the dim light melatonin onset.J Biol Rhythms. 2015; 30: 449-453
- A new method for measuring daytime sleepiness: the Epworth sleepiness scale.Sleep. 1991; 14: 540-545
- Validation of the Brazilian Portuguese version of the Pittsburgh Sleep Quality Index.Sleep Med. 2011; 12: 70-75
- The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.Psychiatry Res. 1989; 28: 193-213
- Evolving antiepileptic drug treatment in juvenile myoclonic epilepsy.Arch Neurol. 2003; 60: 1100-1105
- What can we do for people with drug-resistant epilepsy? The 2016 Wartenberg Lecture.Neurology. 2016; 87: 2483-2489
Spielberger C.D., G.R.L., Lushene R.D. STAI: manual for the state – trait anxiety inventory., 1970.
- Psychometric properties of the Portuguese version of the State-Trait Anxiety Inventory applied to college students: factor analysis and relation to the Beck Depression Inventory.Braz J Med Biol Res. 2001; 34: 367-374
- Prevalence and quality of anxiety in patients with epilepsy.Epilepsy Behav. 2014; 32: 34-37
- Hospital Anxiety and Depression Scale-Anxiety subscale (HADS-A) and The State-Trait Anxiety Inventory (STAI) accuracy for anxiety disorders detection in drug-resistant mesial temporal lobe epilepsy patients.J Affect Disord. 2019; 246: 452-457
- Prognosis of juvenile myoclonic epilepsy is related to endophenotypes.Seizure. 2011; 20: 42-48
- An inventory for measuring depression.Arch Gen Psychiatry. 1961; 4: 561-571
- (B.A.T.B.T.A.e.)Applications of the Beck Depression Inventory.in: Sartorius N. Assessment of Depression. Springer, Berlin, Heidelberg1986 (B.T.A.e.)
- Psychodiagnostic test usage: a survey of the society for personality assessment.J Pers Assess. 1985; 49: 115-119
- The enemy who sealed the world: effects quarantine due to the COVID-19 on sleep quality, anxiety, and psychological distress in the Italian population.Sleep Med. 2020; 75: 12-20
- Predictors of psychological distress and sleep quality in former family caregivers of people with dementia.Aging Ment Health. 2020; 24: 233-241
- Association between sleep and serious psychological distress in patients with diabetes.Psychol Health Med. 2019; 24: 925-935
- Altered polysomnographic profile in juvenile myoclonic epilepsy.Epilepsy Res. 2014; 108: 459-467
- Juvenile myoclonic epilepsy of Janz.Neurology. 1984; 34: 285-294
Article info
Publication history
Published online: November 08, 2022
Accepted:
November 5,
2022
Received in revised form:
October 19,
2022
Received:
August 3,
2022
Identification
Copyright
© 2022 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
