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Department of Pediatrics, The Third Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Neurology, The Children's Hospital of Hebei Province, Affiliated to Hebei Medical University, Shijiazhuang, Hebei, China
MOG was identified in the late 1970s as a central nervous system (CNS) specific protein expressed on the surface of myelin sheath and oligodendrocytes. In pediatric demyelinating diseases, MOG antibodies were first described in 2007 , and Mariotto  reported that MOG-IgG was detected in up to 40% of pediatric patients with acquired demyelinating syndromes (ADS) of the CNS. MOG antibody-mediated central nervous system demyelinating diseases have a variety of phenotypes, including optic neuritis (ON), myelitis, acute disseminated encephalomyelitis (ADEM), and brain stem/cortical encephalitis.