- •PGES is common after GCS and the incidence of PGES in GCS varies from 23% to 86%.
- •Longer tonic phase duration in GCS increases the likelihood of having PGES in GCS.
- •Sleep state at GCS onset and age of epilepsy onset show significant association with PGES occurrence in GCS.
- •The presence of postictal immobility and oxygen desaturation nadir are also related to PGES occurrence in GCS.
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- Sudden unexpected death in epilepsy.Lancet. 2011; 378: 2028-2038
- Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention.Lancet Neurol. 2016; 15: 1075-1088
- Do antiepileptic drugs or generalized tonic-clonic seizure frequency increase SUDEP risk? A combined analysis.Epilepsia. 2012; 53: 249-252
- An electroclinical case-control study of sudden unexpected death in epilepsy.Ann Neurol. 2010; 68: 787-796
- Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study.Lancet Neurol. 2013; 12: 966-977
- Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP).Neurology. 2019; 92: e171-e182
- Postictal generalized EEG suppression and postictal immobility: what do we know?.Epileptic Disord. 2020; 22: 245-251
- Equivocal significance of post-ictal generalized EEG suppression as a marker of SUDEP risk.Seizure. 2017; 48: 28-32
- Postictal generalized electroencephalographic suppression is associated with generalized seizures.Epilepsy Behav. 2011; 21: 271-274
- Postictal generalized EEG suppression: an inconsistent finding in people with multiple seizures.Neurology. 2013; 81: 1252-1256
- Age-specific periictal electroclinical features of generalized tonic-clonic seizures and potential risk of sudden unexpected death in epilepsy (SUDEP).Epilepsy Behav. 2013; 29: 289-294
- Nocturnal seizures are associated with more severe hypoxemia and increased risk of postictal generalized EEG suppression.Epilepsia. 2017; 58: e127-e131
- Risk factors of postictal generalized EEG suppression in generalized convulsive seizures.Neurology. 2015; 85: 1598-1603
- Two predictors of postictal generalized EEG suppression: tonic phase duration and postictal immobility period.Seizure. 2018; 61: 135-138
- Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures.Epilepsy Behav. 2021; 122108228
- Postictal immobility and generalized EEG suppression are associated with the severity of respiratory dysfunction.Epilepsia. 2016; 57: 412-417
- Postictal generalized EEG suppression is not associated with periictal cardiac autonomic instability in people with convulsive seizures.Epilepsia. 2013; 54: 523-529
- Autonomic dysregulation in children with epilepsy with postictal generalized EEG suppression following generalized convulsive seizures.Epilepsy Behav. 2020; 102106688
- Postictal generalized EEG suppression and respiratory dysfunction following generalized tonic-clonic seizures in sleep and wakefulness.Epilepsia. 2017; 58: 1409-1414
- Hypoxemia following generalized convulsive seizures: risk factors and effect of oxygen therapy.Neurology. 2019; 92: e183-e193
- Impact of periictal interventions on respiratory dysfunction, postictal EEG suppression, and postictal immobility.Epilepsia. 2013; 54: 377-382
- Periictal electroclinical characteristics of postictal generalized electroencephalographic suppression after generalized convulsive seizures.Medicine. 2020; 99: e19940
- Tonic phase of a generalized convulsive seizure is an independent predictor of postictal generalized EEG suppression.Epilepsia. 2013; 54: 858-865
- Postictal generalized EEG suppression after generalized convulsive seizures: a double-edged sword.Clin Neurophysiol. 2016; 127: 2078-2084
- Automated analysis of risk factors for postictal generalized EEG suppression.Front Neurol. 2021; 12669517
- Prevention of sudden unexpected death in epilepsy: current status and future perspectives.Expert Rev Neurother. 2020; 20: 497-508
- Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.Ann Int Med. 2009; 151 (W264): 264-269
- Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE Commission for Classification and Terminology.Epilepsia. 2017; 58: 522-530
Wells G.A., Shea B., O'Connell D., Peterson J., Losos M., Tugwell P., et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp0 (accessed 15/03/2018).
- A methodological review of how heterogeneity has been examined in systematic reviews of diagnostic test accuracy.Health Technol Assess. 2005; 9 (iii): 1-113
- Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.Biometrics. 2000; 56: 455-463
- Ictal symmetric tonic extension posturing and postictal generalized EEG suppression arising from sleep in children with epilepsy.Pediatr Neurol. 2017; 76: 54-59
- Postictal generalized EEG suppression is linked to seizure-associated respiratory dysfunction but not postictal apnea.Epilepsia. 2012; 53: 825-831
- Sudden death in epilepsy recorded in ambulatory EEG.J Neurol Neurosurg Psychiatry. 2007; 78: 1395-1397
- Impaired consciousness in epilepsy investigated by a prospective responsiveness in epilepsy scale (RES).Epilepsia. 2012; 53: 437-447
- How do seizures stop?.Epilepsia. 2008; 49: 1651-1664
- Incidence, recurrence, and risk factors for peri-ictal central apnea and sudden unexpected death in epilepsy.Front Neurol. 2019; 10: 166
- Impaired serotonergic brainstem function during and after seizures.J Neurosci. 2016; 36: 2711-2722
- The serotonin axis: shared mechanisms in seizures, depression, and SUDEP.Epilepsia. 2011; 52 (Suppl): 28-38
- The sudden infant death syndrome.N Engl J Med. 2009; 361: 795-805
- Symptomatology of epileptic seizures in the first three years of life.Epilepsia. 1999; 40: 837-844
- Do generalized tonic-clonic seizures in infancy exist?.Neurology. 2005; 65: 1750-1753
- Sudden unexplained death among subjects with refractory epilepsy.Epilepsia. 1996; 37: 931-935
- 3rd Sudden unexplained death in children with epilepsy.Neurology. 2001; 57: 430-434
- Cohort study of incidence of sudden unexplained death in persons with seizure disorder treated with antiepileptic drugs in Saskatchewan, Canada.Epilepsia. 1995; 36: 29-36
- Impact of periictal nurse interventions on postictal generalized EEG suppression in generalized convulsive seizures.Epilepsy Behav. 2016; 58: 22-25