Seizure: European Journal of Epilepsy
Volume 19, Issue 7 , Pages 432-438 , September 2010

Quality of life and treatment satisfaction in Spanish epilepsy patients on monotherapy with lamotrigine or valproic acid

  • C. Viteri

      Affiliations

    • Neurology Department, Clínica Universidad de Navarra, Avenida de Pío XII, 36, 31008 Pamplona, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 948255400; fax: +34 948296500.
  • ,
  • M. Codina

      Affiliations

    • Neurology Department, Hospital German Trias i Pujol, Carretera de Canyet s/n, 08916 Badalona, Spain
  • ,
  • S. Cobaleda

      Affiliations

    • Medical Department, GlaxoSmithKline S.A., Calle Severo Ochoa, 2, 28760 Tres Cantos, Spain
  • ,
  • J. Lahuerta

      Affiliations

    • Medical Department, GlaxoSmithKline S.A., Calle Severo Ochoa, 2, 28760 Tres Cantos, Spain
  • ,
  • J. Barriga

      Affiliations

    • Neurology Department, Hospital Fundación Alcorcón, Calle Budapest, 1, 28922 Madrid, Spain
  • ,
  • M.D. Morales

      Affiliations

    • Neurology Department, Hospital Virgen de la Macarena, Avenida Dr. Fedriani, 3, 41009 Sevilla, Spain
  • ,
  • for the Spanish QOLIE-10 Validation Study Group

Received 23 March 2010 ,Accepted 17 June 2010.

References 

  1. World Health Organization . Epilepsy. Fact sheets no. 999. WHO; 2009;Available from: http://www.who.int/mediacentre/factsheets/fs999/en/index.html [accessed 18.03.09]
  2. Sridharan R. Epidemiology of epilepsy. Curr Sci. 2002;82:664–670
  3. Kaminow L, Schimschock JR, Hammer AE, Vuong A. Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. Epilepsy Behav. 2003;4:659–666
  4. Christensen J, Kjeldsen MJ, Andersen H, Friis ML, Sidenius P. Gender differences in epilepsy. Epilepsia. 2005;46:956–960
  5. Frye CA. Hormonal influences on seizures: basic neurobiology. Int Rev Neurobiol. 2008;83:27–77
  6. Crawford P, Appleton R, Betts T, Duncan J, Guthrie E, Morrow J. Best practice guidelines for the management of women with epilepsy. The Women with Epilepsy Guidelines Development Group. Seizure. 1999;8:201–217
  7. Perucca E. Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs. 2002;16:695–714
  8. Feely M. Fortnightly review: drug treatment of epilepsy. BMJ. 1999;318:106–109
  9. Allain H, Schück S, Nachit-Ouineckh F, Plouin P, Brunon AM, Boulliat J. Improvement in quality of life after initiation of lamotrigine therapy in patients with epilepsy in a naturalistic treatment setting. Seizure. 2007;16:173–184
  10. Aldenkamp AP, Baker G. A systematic review of the effects of lamotrigine on cognitive function and quality of life. Epilepsy Behav. 2001;2:85–91
  11. Mackay FJ, Wilton LV, Pearce GL, Freemantle SN, Mann RD. Safety of long-term lamotrigine in epilepsy. Epilepsia. 1997;38:881–886
  12. Schlienger RG, Shapiro LE, Shear NH. Lamotrigine-induced severe cutaneous adverse reactions. Epilepsia. 1998;39(Suppl. 7):S22–S26
  13. Stavem K, Loge JH, Kaasa S. Health status of people with epilepsy compared with a general reference population. Epilepsia. 2000;41:85–90
  14. Guekht AB, Mitrokhina TV, Lebedeva AV, Dzugaeva FK, Milchakova LE, Lokshina OB, et al. Factors influencing on quality of life in people with epilepsy. Seizure. 2007;16:128–133
  15. Wagner AK, Bungay KM, Kosinski M, Bromfield EB, Ehrrenberg BL. The health status of adults with epilepsy compared with that of people without chronic conditions. Pharmacotherapy. 1996;16:1–9
  16. Ware JE, Sherbourne CD. The MOS 36-item short form health survey (SF-36). Med Care. 1992;30:473–483
  17. Torres X, Arroyo S, Araya S, de Pablo J. The Spanish version of the Quality of Life in Epilepsy Inventory (QOLIE-31): translation, validity, and reliability. Epilepsia. 1999;40:1299–1304
  18. Viteri C, Codina M, Cobaleda S, Lahuerta J, Barriga J, Barrera S, et al. Validación de la versión española del cuestionario de calidad de vida en epilepsia QOLIE-10. Neurología. 2008;23:157–167
  19. Cramer JA, Van Hammée G N132 Study Group. Maintenance of improvement in health-related quality of life during long-term treatment with levetiracetam. Epilepsy Behav. 2003;4:118–123
  20. Loiseau PJ. Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe. Epilepsia. 1999;40(Suppl. 6):S3–S8
  21. Steinhoff BJ, Ueberall MA, Siemes H, Kurlemann G, Schmitz B, Bergmann L, et al. The LAM-SAFE Study: lamotrigine versus carbamazepine or valproic acid in newly diagnosed focal and generalised epilepsies in adolescents and adults. Seizure. 2005;14:597–605
  22. Sackellares JC, Kwong WJ, Vuong A, Hammer AE, Barrett PS. Lamotrigine monotherapy improves health-related quality of life in epilepsy: a double-blind comparison with valproate. Epilepsy Behav. 2002;3:376–382
  23. Balabanov PP, Zahariev ZI, Mateva NG. Evaluation of the factors affecting the quality of life and total costs in epilepsy patients on monotherapy with carbamazepine and valproate. Folia Med (Plovdiv). 2008;50:18–23
  24. Marson AG, Appleton R, Baker GA, Chadwick DW, Doughty J, Eaton B, et al. A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial. Health Technol Assess. 2007;11:iii–iv, ix–x, 1–134
  25. Aldenkamp AP, Van Donselaar CA, Flamman H, Lafarre DLW. Psychosocial reactions to the epilepsy in an unselected group of patients with epilepsy under treatment in general hospitals. Seizure. 2003;12:101–106
  26. Piazzini A, Beghi E, Turner K, Ferraroni M LICE Quality of Life Group. Health-related quality of life in epilepsy: findings obtained with a new Italian instrument. Epilepsy Behav. 2008;13:119–126
  27. Vazquez B, Gibson P, Kustra R. Epilepsy and women's health issues: unmet needs—survey results from women with epilepsy. Epilepsy Behav. 2007;10:163–169
  28. Biton V, Mirza W, Montouris G, Vuong A, Hammer AE, Barrett PS. Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. Neurology. 2001;56:172–177

PII: S1059-1311(10)00143-3

doi: 10.1016/j.seizure.2010.06.014

Seizure: European Journal of Epilepsy
Volume 19, Issue 7 , Pages 432-438 , September 2010