Seizure: European Journal of Epilepsy
Volume 19, Issue 7 , Pages 414-420 , September 2010

Status epilepticus alters hippocampal PKAβ and PKAγ expression in mice

  • Jian Xin Liu

      Affiliations

    • Institute of Neurobiology, School of Medicine, Xi’an Jiaotong University, Xi’an, PR China
    • Temasek Laboratories, National University of Singapore, Singapore
  • ,
  • Yong Cheng Tang

      Affiliations

    • Temasek Laboratories, National University of Singapore, Singapore
  • ,
  • Yong Liu

      Affiliations

    • Institute of Neurobiology, School of Medicine, Xi’an Jiaotong University, Xi’an, PR China
  • ,
  • Feng Ru Tang

      Affiliations

    • Temasek Laboratories, National University of Singapore, Singapore
    • Department of Anatomy, National University of Singapore, Singapore
    • Corresponding Author InformationCorresponding author at: Temasek Laboratories, National University of Singapore, 5A Engineering Drive 1, #06-27, Singapore 117411, Singapore. Tel.: +65 66011094; fax: +65 68726840.

Received 9 September 2009 ,Revised 12 June 2010 ,Accepted 17 June 2010.

References 

  1. Haug T, Storm JF. Protein kinase A mediates the modulation of the slow Ca(2+)-dependent K(+) current, I(sAHP), by the neuropeptides CRF, VIP, and CGRP in hippocampal pyramidal neurons. J Neurophysiol. 2000;83:2071–2079
  2. Lien CC, Martina M, Schultz JH, Ehmke H, Jonas P. Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurons of rat hippocampus. J Physiol. 2002;538(Pt 2):405–419
  3. Chen C, Bazan NG. Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons. J Neurophysiol. 2005;93:929–941
  4. Zsiros V, Maccaferri G. Noradrenergic modulation of electrical coupling in GABAergic networks of the hippocampus. J Neurosci. 2008;28:1804–1815
  5. Tehrani MH, Barnes . Reduced function of gamma-aminobutyric acidA receptors in tottering mouse brain: role of cAMP-dependent protein kinase. Epilepsy Res. 1995;22:13–21
  6. Yechikhov S, Morenkov E, Chulanova T, Godukhin O, Shchipakina T. Involvement of cAMP- and Ca(2+)/calmodulin-dependent neuronal protein phosphorylation in mechanisms underlying genetic predisposition to audiogenic seizures in rats. Epilepsy Res. 2001;46:15–25
  7. Niimura M, Moussa R, Bissoon N, Ikeda-Douglas C, Milgram NW, Gurd JW. Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus. J Neurochem. 2005;92:1377–1385
  8. Vázquez-López A, Sierra-Paredes G, Sierra-Marcuño G. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochem Res. 2005;30:613–618
  9. Ure A, Altrup U. Block of spontaneous termination of paroxysmal depolarizations by forskolin (buccal ganglia, Helix pomatia). Neurosci Lett. 2006;392:10–15
  10. Rakhade SN, Zhou C, Aujla PK, Fishman R, Sucher NJ, Jensen FE. Early alterations of AMPA receptors mediate synaptic potentiation induced by neonatal seizures. J Neurosci. 2008;28:7979–7990
  11. Atzori M, Lau D, Tansey EP, Chow A, Ozaita A, Rudy B, et al. H2 histamine receptor-phosphorylation of Kv3.2 modulates interneuron fast spiking. Nat Neurosci. 2000;3:791–798
  12. Tang FR, Chia SC, Chen PM, Gao H, Lee WL, Yeo TS, et al. Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus. Epilepsy Res. 2004;59:167–180
  13. Liu JX, Tang YC, Liu Y, Tang FR. mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice. Epilepsy Res. 2008;82:111–123
  14. Leidenheimer NJ, Machu TK, Endo S, Olsen RW, Harris RA, Browning MD. Cyclic AMP-dependent protein kinase decreases gamma-aminobutyric acid A receptor-mediated 36Cl-uptake by brain microsacs. J Neurochem. 1991;57:722–725
  15. Lilly SM, Zeng XJ, Tietz EI. Role of protein kinase A in GABAA receptor dysfunction in CA1 pyramidal cells following chronic benzodiazepine treatment. J Neurochem. 2003;85:988–998
  16. Wang LY, Salter MW, MacDonald JF. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science. 1991;253:1132–1135
  17. Cheung HH, Teves L, Wallace MC, Gurd JW. Increased phosphorylation of the NR1 subunit of the NMDA receptor following cerebral ischemia. J Neurochem. 2001;78:1179–1182
  18. Vanhoose AM, Clements JM, Winder DG. Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors. J Neurosci. 2006;26:138–145
  19. Heifets BD, Chevaleyre V, Castillo PE. Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin. Proc Natl Acad Sci USA. 2008;105:10250–10255
  20. Pedarzani P, Storm JF. PKA mediates the effects of monoamine transmitters on the K+ current underlying the slow spike frequency adaptation in hippocampal neurons. Neuron. 1993;11:1023–1035
  21. Few WP, Scheuer T, Catterall WA. Dopamine modulation of neuronal Na(+) channels requires binding of A kinase-anchoring protein 15 and PKA by a modified leucine zipper motif. Proc. Natl Acad Sci USA. 2007;104:5187–5192
  22. Cadd G, McKnight GS. Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain. Neuron. 1989;3:71–79
  23. Sato T, Sato-Harada R, Takano M, Kato S, Saburi S, Harada A. Localization of cAMP-dependent protein kinase in the actin and microtubule cytoskeletons in mouse hippocampal neurons. Neurosci Lett. 2002;325:83–86
  24. Huang YY, Kandel ER, Varshavsky L, Brandon EP, Qi M, Idzerda RL, et al. A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning. Cell. 1995;83:1211–1222
  25. Bracey JM, Kurz JE, Low B, Churn SB. Prolonged seizure activity leads to increased protein kinase A activation in the rat pilocarpine model of status epilepticus. Brain Res. 2009;1283:167–176
  26. Liu JX, Cao X, Tang YC, Liu Y, Tang FR. CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus. J Neurochem. 2007;100:1072–1088
  27. Tang FR, Chia SC, Zhang S, Chen PM, Gao H, Liu CP, et al. Glutamate receptor 1 immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine induced status epilepticus. Eur J Neurosci. 2005;21:2361–2374
  28. Tang FR, Chia SC, Jiang FL, Ma DL, Chen PM, Tang YC. Calcium binding protein containing neurons in the gliotic mouse hippocampus with special reference to their afferents from the medial septum and the entorhinal cortex. Neuroscience. 2006;140:1467–1479
  29. Greengard P, Jen J, Nairn AC, Stevens CF. Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons. Science. 1991;253:1135–1138
  30. Poisbeau P, Cheney MC, Browning MD, Mody I. Modulation of synaptic GABAA receptor function by PKA and PKC in adult hippocampal neurons. J Neurosci. 1999;19:674–683

 Supported by research grant (No: NMRC/0960/2005) from the National Medical Research Council (NMRC) of Singapore as trainee in Epilepsy Research Lab. This study was supported by NMRC grants (No: NMRC/0960/2005) and Singhealth Research Foundation (Nos: SHF/FG217P/2005 and SHF/FG382P/2007) to FR Tang and Guang Hua medical research grant (0203411) from Xi’an Jiaotong University.

PII: S1059-1311(10)00137-8

doi: 10.1016/j.seizure.2010.06.008

Seizure: European Journal of Epilepsy
Volume 19, Issue 7 , Pages 414-420 , September 2010