Seizure: European Journal of Epilepsy
Volume 19, Issue 7 , Pages 439-442 , September 2010

Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans

  • Rakesh Pandey

      Affiliations

    • Central Institute of Medicinal & Aromatic Plants (CSIR), Lucknow 226015, India
    • ,
  • Shipra Gupta

      Affiliations

    • Central Institute of Medicinal & Aromatic Plants (CSIR), Lucknow 226015, India
    • ,
  • Sudeep Tandon

      Affiliations

    • Central Institute of Medicinal & Aromatic Plants (CSIR), Lucknow 226015, India
    • ,
  • Olaf Wolkenhauer

      Affiliations

    • System Biology & Bioinformatics, University of Rostock, 18051 Rostock, Germany
    • ,
  • Julio Vera

      Affiliations

    • System Biology & Bioinformatics, University of Rostock, 18051 Rostock, Germany
    • ,
  • Shailendra K. Gupta

      Affiliations

    • System Biology & Bioinformatics, University of Rostock, 18051 Rostock, Germany
    • Indian Institute of Toxicology Research (CSIR), Lucknow 226001, India
    • Corresponding Author InformationCorresponding author at: System Biology & Bioinformatics, University of Rostock, 18051 Rostock, Germany. Tel.: +49 381 4987575; Indian Institute of Toxicology Research (CSIR), Post Box - 80, MG Marg, Lucknow 226001 India. Tel.: +91 522 2284591.

Received 5 January 2010 ,Revised 25 May 2010 ,Accepted 4 June 2010.

  • Image Result

    Structure of Baccoside A, a triterpenoid saponin from Bacopa monnieri

    Structure of Baccoside A, a triterpenoid saponin from Bacopa monnieri

  • Image Result

    Observations of seizures/convulsions in C. elegans. (A) Effect of temperature on the swimming behavior. (B and C) Alternating dorsal and ventral body bends pattern in normal swimming and seizure burst

    Observations of seizures/convulsions in C. elegans. (A) Effect of temperature on the swimming behavior. (B and C) Alternating dorsal and ventral body bends pattern in normal swimming and seizure burst. (D) Seizures/convulsions behaviors with repeated unilateral contraction. (E) Continuous convulsions and paralytic body bend patterns.

  • Image Result
    Effect of Baccoside A on seizure sensitivity and paralysis of C. elegans at 26–28±1°C. Error bar indicates the standard deviation.

    Effect of Baccoside A on seizure sensitivity and paralysis of C. elegans at 26–28±1°C. Error bar indicates the standard deviation.

  • Image Result
    Effect of Baccoside A on seizure intensity in C. elegans at 26–28±1°C. Error bar indicates the standard deviation.

    Effect of Baccoside A on seizure intensity in C. elegans at 26–28±1°C. Error bar indicates the standard deviation.

PII: S1059-1311(10)00119-6

doi: 10.1016/j.seizure.2010.06.005

Seizure: European Journal of Epilepsy
Volume 19, Issue 7 , Pages 439-442 , September 2010

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