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Volume 19, Issue 7, Pages 439-442 (September 2010)


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Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans

Rakesh Pandeya, Shipra Guptaa, Sudeep Tandona, Olaf Wolkenhauerb, Julio Verab, Shailendra K. GuptabcCorresponding Author Informationemail addressemail address

Received 5 January 2010; received in revised form 25 May 2010; accepted 4 June 2010. published online 05 July 2010.

Abstract 

The 1mm long Caenorhabditis elegans is one of the prime research tools to study different human neurodegenerative diseases. We have considered the case in which increase in the surrounding temperature of this multicellular model leads to abnormal bursts of neuronal cells that can be linked to seizure or convulsion. The induction of such seizure/convulsion mechanism was done by gradually increasing the temperature with 1× buffer (100mM NaCl, 50mM MgCl2) in adult C. elegans. In the present experiment it is demonstrated that Baccoside A can significantly reduce the seizure/convulsion in C. elegans at higher temperatures (26–28±1°C). Furthermore, in T-type Ca2+ channel cca-1 mutant worms, no convulsion was recorded. Our experimental results suggest that plant molecules from Bacopa monnieri may be useful in suppressing the seizure/convulsion in worms.

a Central Institute of Medicinal & Aromatic Plants (CSIR), Lucknow 226015, India

b System Biology & Bioinformatics, University of Rostock, 18051 Rostock, Germany

c Indian Institute of Toxicology Research (CSIR), Lucknow 226001, India

Corresponding Author InformationCorresponding author at: System Biology & Bioinformatics, University of Rostock, 18051 Rostock, Germany. Tel.: +49 381 4987575; Indian Institute of Toxicology Research (CSIR), Post Box - 80, MG Marg, Lucknow 226001 India. Tel.: +91 522 2284591.

PII: S1059-1311(10)00119-6

doi:10.1016/j.seizure.2010.06.005


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