Detection of epileptic spikes by magnetoencephalography and electroencephalography after sleep deprivation

Study outline.

Etiologies of epilepsies of all patients with focal and generalized epilepsies included in this study.

(A) Sensitivity of MEG compared to EEGsd in all patients of this study; (B) sensitivity of M/EEG compared to EEGsd in all patients who had simultaneous M/EEG and EEGsd; (C) comparison of sensitivity of M/EEG and MR-positive/negative patients in all patients who had simultaneous M/EEG and (D) comparison of EEGsd and MRI in the same group of patients. y-Axis: percent, x-axis: total number of patients included in this analysis, labels: total number of patients in each group.

This figure shows the relation of M/EEG and EEGsd recordings to MRI findings and focus hypotheses. Positive/negative M/EEG (upper part) and EEGsd (lower part) in patients who had simultaneous M/EEG with MR-negative/-positive epilepsy and neocortical/temporomesial hypotheses of the epileptic focus (n=49 patients). In contrast to EEGsd M/EEG recorded epileptic spikes in all MR negative patients, while negative MRI was more often related to neocortical focus hypothesis. In MR positive cases M/EEG also recorded more often epileptic spikes than EEGsd. This effect was even more pronounced in patients with temporo-mesial focus hypothesis.