Seizure: European Journal of Epilepsy
Volume 19, Issue 7 , Pages 390-396 , September 2010

Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery

  • Annelies Van Dycke

      Affiliations

    • Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, 1K12, 185 De Pintelaan, 9000 Ghent, Belgium
    • Corresponding Author InformationCorresponding author. Tel.: +32 9 332 6946; fax: +32 9 332 4971.
    • ,
  • Robrecht Raedt

      Affiliations

    • Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, 1K12, 185 De Pintelaan, 9000 Ghent, Belgium
    • ,
  • Alain Verstraete

      Affiliations

    • Laboratory of Clinical Biology, Ghent University Hospital, Ghent, Belgium
    • ,
  • Panos Theofilas

      Affiliations

    • Robert Stone Dow Neurobiology Laboratories, Legacy Research, Portland, OR, USA
    • ,
  • Wytse Wadman

      Affiliations

    • Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, 1K12, 185 De Pintelaan, 9000 Ghent, Belgium
    • Swammerdam Institute of Life Sciences, Department of Neurobiology, University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Kristl Vonck

      Affiliations

    • Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, 1K12, 185 De Pintelaan, 9000 Ghent, Belgium
    • ,
  • Detlev Boison

      Affiliations

    • Robert Stone Dow Neurobiology Laboratories, Legacy Research, Portland, OR, USA
    • ,
  • Paul Boon

      Affiliations

    • Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, 1K12, 185 De Pintelaan, 9000 Ghent, Belgium

Received 31 March 2010 ,Revised 8 May 2010 ,Accepted 21 May 2010.

References 

  1. Forsgren L, Beghi E, Oun A, Sillanpaa M. The epidemiology of epilepsy in Europe—a systematic review. Eur J Neurol. 2005;12:245–253
  2. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935–1984. Epilepsia. 1993;34:453–468
  3. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000;342:314–319
  4. Fisher RS, Ho J. Potential new methods for antiepileptic drug delivery. CNS Drugs. 2002;16:579–593
  5. Fisher RS, Chen DK. New routes for delivery of anti-epileptic medications. Acta Neurol Taiwan. 2006;15:225–231
  6. Dunwiddie TV. Adenosine and suppression of seizures. Adv Neurol. 1999;79:1001–1010
  7. Benarroch EE. Adenosine and its receptors: multiple modulatory functions and potential therapeutic targets for neurologic disease. Neurology. 2008;70:231–236
  8. Fredholm BB, Chen JF, Masino SA, Vaugeois JM. Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs. Annu Rev Pharmacol Toxicol. 2005;45:385–412
  9. Boison D, Scheurer L, Tseng JL, Aebischer P, Mohler H. Seizure suppression in kindled rats by intraventricular grafting of an adenosine releasing synthetic polymer. Exp Neurol. 1999;160:164–174
  10. Boison D. Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies. Epilepsy Res. 2009;85:131–141
  11. Guttinger M, Fedele D, Koch P, Padrun V, Pralong WF, Brustle O, et al. Suppression of kindled seizures by paracrine adenosine release from stem cell-derived brain implants. Epilepsia. 2005;46:1162–1169
  12. Guttinger M, Padrun V, Pralong WF, Boison D. Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts. Exp Neurol. 2005;193:53–64
  13. Huber A, Padrun V, Deglon N, Aebischer P, Mohler H, Boison D. Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proc Natl Acad Sci USA. 2001;98:7611–7616
  14. Szybala C, Pritchard EM, Lusardi TA, Li T, Wilz A, Kaplan DL, et al. Antiepileptic effects of silk-polymer based adenosine release in kindled rats. Exp Neurol. 2009;219:126–135
  15. Wilz A, Pritchard EM, Li T, Lan JQ, Kaplan DL, Boison D. Silk polymer-based adenosine release: therapeutic potential for epilepsy. Biomaterials. 2008;29:3609–3616
  16. Boison D. Cell and gene therapies for refractory epilepsy. Curr Neuropharmacol. 2007;5:115–125
  17. Nilsen KE, Cock HR. Focal treatment for refractory epilepsy: hope for the future?. Brain Res Brain Res Rev. 2004;44:141–153
  18. Raedt R, Van Dycke A, Vonck K, Boon P. Cell therapy in models for temporal lobe epilepsy. Seizure. 2007;16:565–578
  19. Boison D. Adenosine kinase, epilepsy and stroke: mechanisms and therapies. Trends Pharmacol Sci. 2006;27:652–658
  20. Boison D. The adenosine kinase hypothesis of epileptogenesis. Prog Neurobiol. 2008;84:249–262
  21. Studer FE, Fedele DE, Marowsky A, Schwerdel C, Wernli K, Vogt K, et al. Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Neuroscience. 2006;142:125–137
  22. Gouder N, Scheurer L, Fritschy JM, Boison D. Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. J Neurosci. 2004;24:692–701
  23. Li T, Quan LJ, Fredholm BB, Simon RP, Boison D. Adenosine dysfunction in astrogliosis: cause for seizure generation?. Neuron Glia Biol. 2007;3:353–366
  24. Li T, Ren G, Lusardi T, Wilz A, Lan JQ, Iwasato T, et al. Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest. 2008;118:571–582
  25. Li T, Lan JQ, Boison D. Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice. Neuron Glia Biol. 2008;4:91–99
  26. Fedele DE, Koch P, Scheurer L, Simpson EM, Mohler H, Brustle O, et al. Engineering embryonic stem cell derived glia for adenosine delivery. Neurosci Lett. 2004;370:160–165
  27. Li T, Steinbeck JA, Lusardi T, Koch P, Lan JQ, Wilz A, et al. Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants. Brain. 2007;130:1276–1288
  28. Lindvall O, Kokaia Z, Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders—how to make it work. Nat Med. 2004;10(Suppl.):S42–S50
  29. Lindvall O, Kokaia Z. Stem cells for the treatment of neurological disorders. Nature. 2006;441:1094–1096
  30. Li JY, Christophersen NS, Hall V, Soulet D, Brundin P. Critical issues of clinical human embryonic stem cell therapy for brain repair. Trends Neurosci. 2008;31:146–153
  31. Shetty AK, Hattiangady B. Concise review: prospects of stem cell therapy for temporal lobe epilepsy. Stem Cells. 2007;25:2396–2407
  32. Boison D, Scheurer L, Zumsteg V, Rulicke T, Litynski P, Fowler B, et al. Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Proc Natl Acad Sci USA. 2002;99:6985–6990
  33. Parkinson FE, Xiong W. Stimulus- and cell-type-specific release of purines in cultured rat forebrain astrocytes and neurons. J Neurochem. 2004;88:1305–1312
  34. Van Dycke A, Verstraete A, Pil K, Raedt R, Vonck K, Boison D, et al. Quantitative analysis of adenosine using liquid chromatography/atmospheric pressure chemical ionization-tandem mass spectrometry (LC/APCI-MS/MS). J Chromatogr B: Analyt Technol Biomed Life Sci. 2010;878:1493–1498
  35. Kim SU. Genetically engineered human neural stem cells for brain repair in neurological diseases. Brain Dev. 2007;29:193–201
  36. Raedt R, Van Dycke A, Waeytens A, Wyckhuys T, Vonck K, Wadman W, et al. Unconditioned adult-derived neurosphere cells mainly differentiate towards astrocytes upon transplantation in sclerotic rat hippocampus. Epilepsy Res. 2009;87:148–159
  37. Van Dycke A, Raedt R, Dauwe I, Sante T, Wyckhuys T, Meurs A, et al. Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures. Epilepsia 2010, in press.

PII: S1059-1311(10)00114-7

doi: 10.1016/j.seizure.2010.05.010

Seizure: European Journal of Epilepsy
Volume 19, Issue 7 , Pages 390-396 , September 2010

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