Seizure: European Journal of Epilepsy
Volume 19, Issue 6 , Pages 339-346 , July 2010

ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: A systematic review and meta-analysis

  • B.S. Haerian

      Affiliations

    • Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    • Corresponding Author InformationCorresponding author.
  • ,
  • H. Roslan

      Affiliations

    • UKM Medical Molecular Biology Institute, National University of Malaysia, Kuala Lumpur, Malaysia
  • ,
  • A.A. Raymond

      Affiliations

    • Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
  • ,
  • C.T. Tan

      Affiliations

    • Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • ,
  • K.S. Lim

      Affiliations

    • Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • ,
  • S.Z. Zulkifli

      Affiliations

    • UKM Medical Molecular Biology Institute, National University of Malaysia, Kuala Lumpur, Malaysia
  • ,
  • E.H.M. Mohamed

      Affiliations

    • Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • ,
  • H.J. Tan

      Affiliations

    • Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
  • ,
  • Z. Mohamed

      Affiliations

    • Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

Received 14 March 2010 ,Revised 30 April 2010 ,Accepted 7 May 2010.

References 

  1. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935–1984. Epilepsia. 1993;34(3):453–468
  2. Elger CE, Schmidt D. Modern management of epilepsy: a practical approach. Epilepsy Behav. 2008;12:501–539
  3. Schmidt D, Löscher W. Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia. 2005;46(6):858–877
  4. Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta. 1976;455:152–162
  5. Schinkel AH, Smit JJM, Beijnen JH, Wagenaar E, van Deemter L, Mol CAAM, et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood–brain barrier and to increased sensitivity to drugs. Cell. 1994;77:491–502
  6. Löscher W, Potschka H. Blood–brain barrier active efflux transporters: ATP-binding cassette gene family. Epilepsia. 2005;1–23
  7. Komar AA. Silent SNPs: impact on gene function and phenotype. Pharmacogenomics. 2007;8(8):1075–1080
  8. Siddiqui A, Kerb R, Weale ME, Brinkmann U, Smith A, Goldstein DB, et al. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med. 2003;348(15):1442–1448
  9. Leschziner GD, Andrew T, Leach JP, Chadwick D, Coffey AJ, Balding DJ, et al. Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach. Pharmacogenet Genomics. 2007;17(3):217–220
  10. Bournissen FG, Moretti ME, Juurlink DN, Koren G, Walker M, Finkelstein Y. Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis. Epilepsia. 2009;50(4):898–903
  11. Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Hauser WA, Mathern G, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2009;1–9
  12. Bax L, Yu LM, Ikeda N, Tsuruta H, Moons KG. Development and validation of MIX: comprehensive free software for meta-analysis of causal research data. BMC Med Res Methodol. 2006;6(50):1–11
  13. Szoeke C, Sills GJ, Kwan P, Petrovski S, Newton M, Hitiris N, et al. Multidrug-resistancegenotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from International Pharmacogenetic Cohorts. Epilepsia. 2009;(May):
  14. Hung CC, Tai JJ, Lin CJ, Lee MJ, Liou HH. Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response. Pharmacogenomics. 2005;6(4):411–417
  15. Kim DW, Kim M, Lee SK, Kang R, Lee SY. Lack of association between C3435T nucleotide MDR1 genetic polymorphism and multidrug-resistanceepilepsy. Seizure. 2006;15(5):344–347
  16. Kim YO, Kim MK, Woo YJ, Lee MC, Kim JH, Park KW, et al. Single nucleotide polymorphisms in the multidrug resistance 1 gene in Korean epileptics. Seizure. 2006;15(1):67–72
  17. Seo T, Ishitsu T, Ueda N, Nakada N, Yurube K, Ueda K, et al. ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients. Pharmacogenomics. 2006;7(4):551–561
  18. Chen L, Liu CQ, Hu Y, Xiao ZT, Chen Y, Liao JX. Association of a polymorphism in MDR1 C3435T with response to antiepileptic drug treatment in ethic Han Chinese children with epilepsy. Zhongguo Dang Dai Er Ke Za Zhi. 2007;9(1):11–14
  19. Ebid AH, Ahmed MM, Mohammed SA. Therapeutic drug monitoring and clinical outcomes in epileptic Egyptian patients: a gene polymorphism perspective study. Ther Drug Monit. 2007;29(3):305–312
  20. Hung CC, Jen Tai J, Kao PJ, Lin MS, Liou HH. Association of polymorphisms in NR1I2 and ABCB1 genes with epilepsy treatment responses. Pharmacogenomics. 2007;8(9):1151–1158
  21. Kwan P, Baum L, Wong V, Ng PW, Lui CH, Sin NC, et al. Association between ABCB1 C3435T polymorphism and drug-resistanceepilepsy in Han Chinese. Epilepsy Behav. 2007;11(1):112–117
  22. Dericioglu N, Babaoglu MO, Yasar U, Bal IB, Bozkurt A, Saygi S. Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 (MDR1) gene. Epilepsy Res. 2008;80(1):42–46
  23. Ozgon GO, Bebek N, Gul G, Cine N. Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey. Eur Neurol. 2008;59(1–2):67–70
  24. Kim DW, Lee SK, Chu K, Jang IJ, Yu KS, Cho JY, et al. Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy. Epilepsy Res. 2009;84(1):86–90
  25. Kwan P, Wong V, Ng PW, Lui CH, Sin NC, Poon WS, et al. Gene-wide tagging study of association between ABCB1 polymorphisms and multidrug resistance in epilepsy in Han Chinese. Pharmacogenomics. 2009;10(5):723–732
  26. Lakhan R, Misra UK, Kalita J, Pradhan S, Gogtay NJ, Singh MK, et al. No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population. Epilepsy Behav. 2009;14(1):78–82
  27. Vahab SA, Sen S, Ravindran N, Mony S, Mathew A, Vijayan N, et al. Analysis of genotype and haplotype effects of ABCB1 (MDR1) polymorphisms in the risk of medically refractory epilepsy in an Indian population. Drug Metab Pharmacokinet. 2009;24(3):255–260
  28. Hajnsek S, Basic S, Poljakovic Z, Bozina N. Utjecaj C3435T polimorfizma MDR1 gena na ucinkovitost medikamentnog lijecenja epilesia. Neurol Croat. 2004;53:69–78
  29. Soranzo N, Cavalleri GL, Weale ME, Wood NW, Depondt C, Marguerie R, et al. Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene. Genome Res. 2004;14(7):1333–1344
  30. Tan NCK, Heron SE, Scheffer IE, Pelekanos JT, Mc Mahon JM, Vears DF, et al. Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistanceepilepsy. Neurology. 2004;63:1090–1092
  31. Sills GJ, Mohanraj R, Butler E, McCrindle S, Collier L, Wilson EA, et al. Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia. 2005;46(5):643–647
  32. Shahwan A, Murphy K, Doherty C, Cavalleri GL, Muckian C, Dicker P, et al. The controversial association of ABCB1 polymorphisms in refractory epilepsy: an analysis of multiple SNPs in an Irish population. Epilepsy Res. 2007;73(2):192–198
  33. Ufer M, Mosyagin I, Muhle H, Jacobsen T, Haenisch S, Häsler R, et al. Non-response to antiepileptic pharmacotherapy is associated with the ABCC2-24C>T polymorphism in young and adult patients with epilepsy. Pharmacogenet Genomics. 2009;19:353–362
  34. Zimprich F, Sunder-Plassmann R, Stogmann E, Gleiss A, Dal-Bianco A, Zimprich A, et al. Association of an ABCB1 gene haplotype with pharmacoresistance to AEDs in temporal lobe epilepsy. Neurology. 2004;63(6):1087–1089
  35. Leschziner G, Zabaneh D, Pirmohamed M, Owen A, Rogers J, Coffey AJ, et al. Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance. Pharmacogenet Genomics. 2006;16(6):439–450
  36. Cardon LR, Palmer LJ. Population stratification and spurious allelic association. Lancet. 2003;361:598–604
  37. Tan NCK, Mulley JC, Berkovic SF. Genetic association studies in epilepsy: “The truth is out there”. Epilepsia. 2004;45(11):1429–1442
  38. Otto J. Association of genetic loci Replication or not, that is the question. Neurology. 2004;63:955–958
  39. Duncan JS, Sander JW, Sisodiya SM, Walker MC. Adult epilepsy. Lancet. 2006;367:1087–1100
  40. French JA. Refractory epilepsy: one size does not fit all. Epilepsy Curr. 2006;6(6):177–180
  41. Kasperaviciute D, Sisodiya SM. Epilepsy parmacohenetics. Pharmacogenomics J. 2009;10(5):817–836
  42. Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Löscher W. Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007;52:333–346
  43. Baltes S, Fedrowitz M, Tortós CL, Potschka H, Löscher W. Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays. J Pharmacol Exp Ther. 2007;320(1):331–343
  44. Rivers F, O’Brien TJ, Callaghan R. Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations. Eur J Pharmacol. 2008;598(1–3):1–8
  45. Patsalos PN, Fröscher W, Pisani F, van Rijn CM. The importance of drug interactions in epilepsy therapy. Epilepsia. 2002;43(4):365–385
  46. Zintzaras E, Lau J. Synthesis of genetic association studies for pertinent gene-disease associations appropriate methodological and statistical approaches. J Clin Epidemiol. 2008;61:634–645
  47. Cascorbi I. ABC transporters in drug-refractory epilepsy: limited clinical significance of pharmacogenetics?. Clin Pharmacol Ther. 2010;87(1):15–18

PII: S1059-1311(10)00108-1

doi: 10.1016/j.seizure.2010.05.004

Seizure: European Journal of Epilepsy
Volume 19, Issue 6 , Pages 339-346 , July 2010