Seizure: European Journal of Epilepsy
Volume 19, Issue 4 , Pages 242-246 , May 2010

Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus

  • Simone Bittencourt

      Affiliations

    • Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil
    • ,
  • Francisco P. Dubiela

      Affiliations

    • Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil
    • ,
  • Claudio Queiroz

      Affiliations

    • Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil
    • Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil
    • ,
  • Luciene Covolan

      Affiliations

    • Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil
    • ,
  • Danielle Andrade

      Affiliations

    • Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    • ,
  • Andres Lozano

      Affiliations

    • Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    • ,
  • Luiz E. Mello

      Affiliations

    • Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil
    • ,
  • Clement Hamani

      Affiliations

    • Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil
    • Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
    • Corresponding Author InformationCorresponding author at: Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street WW 4-437, M5T2S8 Toronto, ON, Canada. Tel.: +1 416 6035771; fax: +1 416 6035298.

Received 14 October 2009 ,Revised 12 December 2009 ,Accepted 26 February 2010.

References 

  1. Andrade DM, Zumsteg D, Hamani C, Hodaie M, Sarkissian S, Lozano AM, et al. Long-term follow-up of patients with thalamic deep brain stimulation for epilepsy. Neurology. 2006;66:1571–1573
  2. Hamani C, Ewerton FI, Bonilha SM, Ballester G, Mello LE, Lozano AM. Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus. Neurosurgery. 2004;54:191–195[discussion 195–197]
  3. Hodaie M, Wennberg RA, Dostrovsky JO, Lozano AM. Chronic anterior thalamus stimulation for intractable epilepsy. Epilepsia. 2002;43:603–608
  4. Kerrigan JF, Litt B, Fisher RS, Cranstoun S, French JA, Blum DE, et al. Electrical stimulation of the anterior nucleus of the thalamus for the treatment of intractable epilepsy. Epilepsia. 2004;45:346–354
  5. Mirski MA, McKeon AC, Ferrendelli JA. Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures. Brain Res. 1986;397:377–380
  6. Mirski MA, Ferrendelli JA. Anterior thalamic mediation of generalized pentylenetetrazol seizures. Brain Res. 1986;399:212–223
  7. Mirski MA, Rossell LA, Terry JB, Fisher RS. Anticonvulsant effect of anterior thalamic high frequency electrical stimulation in the rat. Epilepsy Res. 1997;28:89–100
  8. Lim SN, Lee ST, Tsai YT, Chen IA, Tu PH, Chen JL, et al. Electrical stimulation of the anterior nucleus of the thalamus for intractable epilepsy: a long-term follow-up study. Epilepsia. 2007;48:342–347
  9. Osorio I, Overman J, Giftakis J, Wilkinson SB. High frequency thalamic stimulation for inoperable mesial temporal epilepsy. Epilepsia. 2007;48:1561–1571
  10. Hamani C, Hodaie M, Chiang J, del Campo M, Andrade DM, Sherman D, et al. Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus. Epilepsy Res. 2008;78:117–123
  11. Lado FA. Chronic bilateral stimulation of the anterior thalamus of kainate-treated rats increases seizure frequency. Epilepsia. 2006;47:27–32
  12. Takebayashi S, Hashizume K, Tanaka T, Hodozuka A. Anti-convulsant effect of electrical stimulation and lesioning of the anterior thalamic nucleus on kainic acid-induced focal limbic seizure in rats. Epilepsy Res. 2007;74:163–170
  13. Takebayashi S, Hashizume K, Tanaka T, Hodozuka A. The effect of electrical stimulation and lesioning of the anterior thalamic nucleus on kainic acid-induced focal cortical seizure status in rats. Epilepsia. 2007;48:348–358
  14. van Groen T, Kadish I, Michael Wyss J. Role of the anterodorsal and anteroventral nuclei of the thalamus in spatial memory in the rat. Behav Brain Res. 2002;132:19–28
  15. Warburton EC, Aggleton JP. Differential deficits in the Morris water maze following cytotoxic lesions of the anterior thalamus and fornix transection. Behav Brain Res. 1999;98:27–38
  16. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Academic Press; 1998;
  17. Turski WA, Cavalheiro EA, Schwarz M, Czuczwar SJ, Kleinrok Z, Turski L. Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res. 1983;9:315–335
  18. Hamani C, Mello LE. Status epilepticus induced by pilocarpine and picrotoxin. Epilepsy Res. 1997;28:73–82
  19. Miller JW, Ferrendelli JA. The central medial nucleus: thalamic site of seizure regulation. Brain Res. 1990;508:297–300
  20. Miller JW, Ferrendelli JA. Characterization of GABAergic seizure regulation in the midline thalamus. Neuropharmacology. 1990;29:649–655
  21. Cassidy RM, Gale K. Mediodorsal thalamus plays a critical role in the development of limbic motor seizures. J Neurosci. 1998;18:9002–9009
  22. Bertram EH, Mangan PS, Zhang D, Scott CA, Williamson JM. The midline thalamus: alterations and a potential role in limbic epilepsy. Epilepsia. 2001;42:967–978
  23. Gallego JM, Ortiz L, Gutierrez R, Barcia JA. Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled rats. Seizure. 2009;18:537–540
  24. Clifford DB, Olney JW, Maniotis A, Collins RC, Zorumski CF. The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures. Neuroscience. 1987;23:953–968
  25. Oda S, Kuroda M, Kakuta S, Kishi K. Differential immunolocalization of m2 and m3 muscarinic receptors in the anteroventral and anterodorsal thalamic nuclei of the rat. Brain Res. 2001;894:109–120
  26. Nonaka R, Moroji T. Quantitative autoradiography of muscarinic cholinergic receptors in the rat brain. Brain Res. 1984;296:295–303
  27. Gonzalo-Ruiz A, Sanz JM, Lieberman AR. Immunohistochemical studies of localization and co-localization of glutamate, aspartate and GABA in the anterior thalamic nuclei, retrosplenial granular cortex, thalamic reticular nucleus and mammillary nuclei of the rat. J Chem Neuroanat. 1996;12:77–84
  28. Smith Y, Seguela P, Parent A. Distribution of GABA-immunoreactive neurons in the thalamus of the squirrel monkey (Saimiri sciureus). Neuroscience. 1987;22:579–591
  29. Wang B, Gonzalo-Ruiz A, Sanz JM, Campbell G, Lieberman AR. Immunoelectron microscopic study of gamma-aminobutyric acid inputs to identified thalamocortical projection neurons in the anterior thalamus of the rat. Exp Brain Res. 1999;126:369–382
  30. Gonzalo-Ruiz A, Lieberman AR. GABAergic projections from the thalamic reticular nucleus to the anteroventral and anterodorsal thalamic nuclei of the rat. J Chem Neuroanat. 1995;9:165–174
  31. Gonzalo-Ruiz A, Lieberman AR. Topographic organization of projections from the thalamic reticular nucleus to the anterior thalamic nuclei in the rat. Brain Res Bull. 1995;37:17–35
  32. Lozano AM, Dostrovsky J, Chen R, Ashby P. Deep brain stimulation for Parkinson's disease: disrupting the disruption. Lancet Neurol. 2002;1:225–231
  33. Vitek JL. Mechanisms of deep brain stimulation: excitation or inhibition. Mov Disord. 2002;17(Suppl. 3):S69–S72
  34. Hamani C, Ewerton FI, Marcolin de Almeida F, Bonilha SM, Covolan L, Fantin Cavarsan C, et al. Bilateral anterior thalamic nucleus lesions are not protective against seizures in chronic pilocarpine epileptic rats. Stereotact Funct Neurosurg. 2009;87:143–147

PII: S1059-1311(10)00053-1

doi: 10.1016/j.seizure.2010.02.010

Seizure: European Journal of Epilepsy
Volume 19, Issue 4 , Pages 242-246 , May 2010

Article Tools

* Image Usage & Resolution