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Volume 19, Issue 3 , Pages 140-146 , April 2010

POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders

Russell P. Saneto
- Division of Pediatric Neurology, Seattle Children's Hospital/University of Washington, Seattle, WA 98105, USA
- These authors contributed equally.
Inn-Chi Lee
- Department of Pediatrics, School of Medicine, Chung Shan Medical University, Taichung, Taiwan
- Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, TX 77030, USA
- These authors contributed equally.
Mary Kay Koenig
- Division of Child & Adolescent Neurology, University of Texas Medical School at Houston, TX 77030, USA
Xinhua Bao
- Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
Shao-Wen Weng
- Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
- Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, TX 77030, USA
Robert K. Naviaux
- Departments of Medicine and Pediatrics, University of California San Diego, La Jolla, CA, USA
Lee-Jun C. Wong
- Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, NAB 2015, Houston, TX 77030, USA
- Corresponding author. Tel.: +1 713 798 1940; fax: +1 713 798 8937.

Received 28 October 2009 ,Revised 31 December 2009 ,Accepted 7 January 2010.

This EEG epoch demonstrates occipital lobe epileptiform discharges of patient 3 at age 3 years. (a) Bipolar montage and predominant right occipital discharges. (b) Same epoch but in a transverse monta

This EEG epoch demonstrates occipital lobe epileptiform discharges of patient 3 at age 3 years. (a) Bipolar montage and predominant right occipital discharges. (b) Same epoch but in a transverse montage. This view shows that the predominant discharge is right occipital. The background rhythm is slow for age. Interestingly, in other EEGs, the occipital discharge was predominantly left occipital.
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This EEG epoch shows generalized epileptiform discharges in a bipolar montage (patient 5). This epoch demonstrates a large amplitude spike and wave discharge (large delta discharge followed by a notch

This EEG epoch shows generalized epileptiform discharges in a bipolar montage (patient 5). This epoch demonstrates a large amplitude spike and wave discharge (large delta discharge followed by a notched spike) at 2–2.5Hz. There is also an intermittent slow that is maximal bi-occipital with left occipital predominance. The background rhythm is slow for age.
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